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EACH STEP YOU TAKE IS UNIQUE TO YOU

LISTEN TO YOUR LEG PAIN

Your walk, your gait — each step you take — is unique to you and your life. It’s crucial to how you explore and experience your world. If you’re living with type 2 diabetes, and you start to experience leg and calf pain while walking that eases with rest, it may be an indication of peripheral artery disease, also known as PAD.3

PAD and type 2 diabetes

Do you have an increased risk of developing PAD?

Peripheral artery disease (PAD) is a circulation problem in the limbs.4,5 Often beginning as pain in the legs, especially in the calves, PAD can be an early sign of future cardiovascular and limb complications.2 This pain may impact mobility and walking longer distances can become more challenging.2,6

Patients living with type 2 diabetes at any stage have nearly double the chance of peripheral artery disease.7,8

 

 

PAD can interrupt life

But early action can make a difference.2

Up to 50% of those living with type 2 diabetes also have peripheral artery disease.4,9 As you navigate your life with type 2 diabetes, it's crucial to pay attention to your body. Your legs could be telling you something important about your overall health.

Recognising PAD early will help you to keep moving through life your way — and it could reduce the risk of future limb and cardiovascular complications.1,2,6

 

 

Take the right next steps

It’s time to listen to your leg pain.

Awareness of your unique symptoms and communication with your doctor are the keys to finding the right treatment in a timely manner.2 For those living with type 2 diabetes and peripheral artery disease, certain medications could help reduce or delay future complications in the limbs.6,10

 

HQ24OZM00112 January 2025

References
  1. Gornik HL, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024 Jun 11;149(24):e1313-e1410.
  2. Nordanstig J, et al. Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication. Eur J Vasc Endovasc Surg. 2024 Jan;67(1):9-96.
  3. Abramson BL, Al-Omran M, et al. Canadian Cardiovascular Society 2022 Guidelines for Peripheral Arterial Disease. Can J Cardiol. 2022;38(5):560-587. ​
  4. Soyoye DO et al. Diabetes and peripheral artery disease: A review. World J Diabetes. 2021;12(6):827-838.
  5. Zemaitis MR et al. Peripheral Arterial Disease. [Updated 2023 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan- Available from: https://www.ncbi.nlm.nih.gov/books/NBK430745
  6. Mazzolai L et al. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases. Eur Heart J. Published online August 30, 2024. doi:10.1093/eurheartj/ehae179​
  7. Sillesen H, et al, Effects of semaglutide on functional capacity in patients with type 2 diabetes and peripheral arterial disease: rationale and design of the STRIDE trial. European Heart Journal. 2021 Oct;42(Supplement_1):ehab724.2027.
  8. Verma S, et al. Epidemiology and Burden of Peripheral Artery Disease in People With Type 2 Diabetes: A Systematic Literature Review. Diabetes Ther. 2024. doi: 10.1007/s13300-024-01606-6.​
  9. Thiruvoipati T et al. Peripheral artery disease in patients with diabetes: Epidemiology, mechanisms, and outcomes. World J Diabetes. 2015;6(7):961-969. ​
  10. Caruso P, Maiorino MI, Longo M, et al. Liraglutide for Lower Limb Perfusion in People With Type 2 Diabetes and Peripheral Artery Disease: The STARDUST Randomized Clinical Trial. JAMA Netw Open. 2024;7(3):e241545. ​
  11. Song P, et al. Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis. Lancet Glob Health. 2019 Aug;7(8):e1020-e1030.